Inflammatory myofibroblastic tumor breast
Inflammatory myofibroblastic tumor breast
Inflammatory myofibroblastic tumor breast. 001 Corpus ID: 43372858; Inflammatory myofibroblastic tumor of the breast. abnormal and excessive tissue Inflammatory myofibroblastic tumor (IMT) is a rare lesion, representing 0. In the clinical practice of breast pathology, immunohistochemistry (IHC) of different markers is widely used for the diagnosis and classification of breast lesions. IMT was previously considered a benign disease; however, it is now recognized to have a risk of local recurrence and distant 'Mammary Myofibroblastoma' published in 'Breast Pathology' Classic-type MFB is a well-circumscribed but nonencapsulated, bland-looking spindle cell tumor which usually does not contain entrapped mammary ducts/lobules (Fig. Inflammatory myofibroblastic tumor (IMT) is a relatively rare neoplasm. They are composed of inflammatory cells and Inflammatory myofibroblastic tumors (IMTs) of the breast represent extremely rare lesions. it has occurred in the genitourinary tract, gastrointestinal tract, and the breast. Breast IMTs are easily misdiagnosed as other types of malignant lesions, and therefore there is a significant unmet need for a better preoperational differential diagnosis based on imaging Inflammatory myofibroblastic tumor (Pathol Res Pract 2023;242:154335) Interdigitating dendritic cell sarcoma (Am J Surg Pathol 2002;26:530) Phyllodes tumor of breast (more common if benign) (J Surg Res 2000;94:84) Pleomorphic fibroma of skin (Semin Diagn Pathol 2023;40:295) Background: The inflammatory myofibroblastic tumor (IMT) is an uncommon low-risk lesion with only a few cases described in the literature. The treatment of choice is surgery, except in cases where surgery is not possible due to localization or if it presents with metastatic disease. This tumor, characterized by its rareness, affects mainly the lung and the orbit. It has characteristic expression of vimentin, CD34, and desmin. 7 Although inflammatory myofibroblastic tumors are more commonly recognized in the lungs, they can also be observed in several other sites including the breasts, liver, spleen, thyroid, pancreas, Furthermore, L576P mutation has been reported in extra-gastrointestinal malignancy , breast cancer , and thymic carcinoma . 5cm (P < 0. Since the bladder IMT was first described in 1980, only more than 100 cases have been reported worldwide (). 8 cm in size was identified at the 9 o'clock position The average tumor sizes were 6. Inflammatory myofibroblastic tumors are rare mesenchymal myofibroblastic lesions of intermediate malignant potential with tendency for local recurrence and rare metastases usually seen within the Inflammatory myofibroblastic tumor (IMT) is a rare neoplasm with intermediate malignancy characterized by a propensity for recurrence but a low metastatic rate. They are composed of fibroblasts and myofibroblasts and Primary inflammatory myofibroblastic tumors (IMTs) of the breast are uncommon and metastasis of IMTs is extremely rare. Although patients with IMTs should undergo regular follow-up after complete surgical resection of the tumor, th Inflammatory myofibroblastic tumor (IMT), characterized by intermediate malignancy and a propensity for recurrence, has presented a formidable clinical challenge in diagnosis and treatment. It mostly occurs in the lung, pelvic, and retroperitoneal soft tissues but rarely in the reproductive system. It seldom results in distant metastasis and has a relatively low recurrence rate, ranging from 2% to 25% in various studies (). Inflammatory myofibroblastic tumors (IMTs) are rare intermediate-grade neoplasms that have a high recurrence rate after excision and exhibit low metastatic potential. While metastases have been reported Inflammatory myofibroblastic tumor (IMT) is a rare tumor with low-grade malignant risk mainly occurring in soft tissues and lungs, and it is extremely rare in the breast. e. While metastases have been reported . Sie entstehen typischerweise in der Lunge und betreffen Kinder oder junge Erwachsene. Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: a case report. This is only the eleventh case reported in the English language literature. The Chavez C, Hoffman MA. 2015. As is the case for other non-small round cell sarcomas, surgical resection remains the standard treatment strategy for inflammatory myofibroblastic Primary inflammatory myofibroblastic tumors (IMTs) of the breast are uncommon and metastasis of IMTs is extremely rare. 2006;64:305–8. Inflammatory myofibroblastic tumor (IMT) is a rare soft-tissue tumor with a clinical resemblance to malignant neoplasm[]. The pathological examination showed pr Inflammatory myofibroblastic tumors (IMTs) of the heart are rarely observed in the eldly. Inflammatory myofibroblastic tumors (IMTs) are uncommon breast lesions that consist of spindle cells accompanied by plasma cell-rich inflammatory infiltration, which may mimic breast cancer Fibromas are tumors (usually benign) that affect connective tissue. Brunn first described it in 1939, but its etiology remains uncertain. To better These tumors contain proliferating neoplastic, fibroblastic and myofibroblastic cells, and are also characterized by chronic inflammatory infiltration by lymphocytes, plasma cells, Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. However, recent findings Introduction: Inflammatory myofibroblastic tumors (IMT) while uncommon may arise within numerous organs. The most common sites are the lung, abdominopelvic region, and retroperitoneum. Pathological staining of the bulk resected tumor after preoperative preparation revealed that the tumor-like tissue was enriched for spindle cells arranged in fascicular clusters. They generally affect younger populations, especially females Inflammatory myofibroblastic tumor (IMT) is generally considered as a benign tumor with aggressive behavior (low-grade tumor), which can occur anywhere in the body DOI: 10. eet. With a predilection for children and young adults, many patients present with systemic symptoms and the tumors demonstrate local invasiveness and even metastasis. Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. The World Health Organization (WHO) 2020 definition of IMT suggests that it is a distinctive, rarely metastasizing neoplasm Introduction: Inflammatory myofibroblastic tumors (IMTs) are intermediate-grade lesions that frequently recur and rarely metastasize. Pathological staining of the bulk resected tumor Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. Over the last two decades, inflammatory myofibroblastic tumour (IMT) has emerged Inflammatory myofibroblastic tumors (IMTs) of the breast represent extremely rare lesions. Surgery was the most common Inflammatory myofibroblastic tumor (IMT) is a term that has been used to describe the entity known as IPT because of the predominance of myofibroblasts and histiocytes. Myofibroblastomas are also sometimes called ‘myogenic stromal tumor‘, and can occur This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of childhood pulmonary inflammatory myofibroblastic tumors. Inflammatory myofibroblastic tumor (IMT), also known as inflammatory pseudotumor and plasmacytoid granuloma, is a tumor commonly occurring in the lungs, abdomen, skin, soft tissues, inflammatory myofibroblastic tumors of the breast with metastasis: radiographic and histopathologic predictive factors. 04% to 0. Inflammatory myofibroblastic tumors (IMTs) are uncommon, mesenchymal neoplasms that are composed of proliferative myofibroblasts and infiltrating inflammatory cells, usually plasma cells and lymphocytes (). Materials and methods: A retrospective study with detailed clinical, radiological, and histopathological (HPE) features along with management and outcome of 10 biopsy Inflammatory myofibroblastic tumor (IMT) is an uncommon lesion of unknown cause. Oncol Lett. Inflammatory myofibroblastic tumors usually occur in children INTRODUCTION. In the present study, we present a case of IMT in a 56-year-old female patient who was admitted to our hospital due to a mass found in her right breast. IMT is a rare junctional/low-grade tumor with the potential for recurrence and progression []; it is mainly composed of myofibroblast spindle cells with inflammatory cell infiltration, including plasma cells, lymphocytes, and eosinophils []. IMTs are Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor. Introduction: Inflammatory myofibroblastic tumor (IMT) is a rare entity, classified within soft tissue sarcomas. Schammel and Lorraine Minobe and Judith Cymerman and inflammatory myofibroblastic tumors of the breast with metastasis: radiographic and histopathologic predictive factors. Inflammatory myofibroblastic tumour (inflammatory pseudotumour) of the breast. 1159/000354250 Published online: August 19, 2013 Inflammatory Myofibroblastic Tumor of the Breast Coexisting with Breast Cancer: A Case Report Jian Lia* Wen Yuna* Jianwei Qina Jianhua Zhaob Xuemin Liuc Jianzhong Wua Minghua Jia Jinhai Tanga a This case presented the opportunity to review studies regarding cases of inflammatory myofibroblastic breast tumors and determine whether they are reactive lesions due to an exaggerated response to tissue injury or indicate a true neoplastic process. A histopathological examination showed the presence of myofibroblastic spindle cells with mixed inflammatory infiltrates, and the pathological Inflammatory myofibroblastic tumor of the distal common bile duct: Literature review with focus on pathological examination. named it so in 1954 for its ability to mimic malignancy clinically and radiologically [Med Pediatr Oncol 2000; 35(5): 484–7]. Inflammatory myofibroblastic tumors (IMTs), particularly breast IMTs, are rare neoplastic lesions typically associated with a favorable prognosis. It Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate biological potential with a predilection for the lung and abdominopelvic region. There are three major types: 1, eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, necrotizing fasciitis (fasciitis Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate malignancy. The exact etiology of bladder IMT remains uncertain, and its most Background: The inflammatory myofibroblastic tumor (IMT) is an uncommon low-risk lesion with only a few cases described in the literature. Because of the We previously reported a case of proteomics-directed treatment of an inflammatory myofibroblastic tumor, but this is the first patient participating in our As a heterogeneous disease, breast cancer (BC) has been characterized by the uncontrolled proliferation of mammary epithelial cells. spleen, breast, pancreas, liver, * Correspondence: mmasarweh@khcc. PMID: 23255901. Case Report: Here, we report a unique case of an IMT coexisting with breast cancer. These tumors contain proliferating neoplastic, fibroblastic and myofibroblastic cells, and are also characterized by chronic inflammatory infiltration by lymphocytes, Background: Inflammatory myofibroblastic tumors (IMTs) are rare intermediate-grade neoplasms that have a high recurrence rate after excision and exhibit low metastatic potential. 1 An IMT is a fibroblastic neoplasm composed of spindle cells accompanied by an inflammatory infiltrate of plasma cells Introduction. 02. Complete remission of ALK-negative plasma cell granuloma (inflammatory myofibroblastic tumor) of the lung induced by celecoxib: A case report and review of Introduction: We report the clinical findings and results of treatment in the cohort of patients with inflammatory myofibroblastic tumor (IMT) managed according to the European pediatric Soft Tissue Sarcoma Study Group (EpSSG) protocol from 2005 to 2016. On ultrasonography (US), these tumours can appear as hypoechoic or hyperechoic masses Inflammatory myofibroblastic tumors (IMTs) of the liver are extremely rare and account for just 0. Xavier As inflammatory myofibroblastic tumors (IMTs) have become more widely recognized in the female genital tract, an intriguing subset of uterine tumors associated with pregnancy has emerged. Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate malignant potential that only rarely involves the gynecologic tract. After initial workup, which suggested an inflammatory Inflammatory myofibroblastic tumors (IMTs) of the lung are a rare type of mesenchymal tumors that tend to occur more in the lungs of children. A 28-year-old woman was referred to our hospital because of abdominal pain, weight loss and a palpable intra-abdominal mass. Mesenchymal tumors of the breast encompass lesions originating from the mammary stroma. IMT weisen Cancer-associated fibroblasts (CAFs) are a prominent stromal cell type in solid tumors and molecules secreted by CAFs play an important role in tumor progression and metastasis. 05). Fleur Cordier, Anne Hoorens, This lesion was discovered incidentally during follow-up imaging of the patient's metastatic breast carcinoma. Often originating from the abdomen or thorax, IMT most commonly affects children and young adults. Inoue M , Ohta T , Shioya H , Sato S , Takahashi H , Nakata N , Taniguchi C , Hirano M , Nishioka M , Yamakawa H Inflammatory myofibroblastic tumor (IMT) is a soft tissue neoplasm which can be locally invasive, recur, or in rare cases metastasize. Herein, we report a rare case of simultaneous multiple primary cancers and inflammatory myofibroblastic tumor. Inflammatory myofibroblastic tumor (IMT), also known as inflammatory pseudotumor and plasmacytoid granuloma, is a tumor commonly occurring in the lungs, abdomen, skin, soft tissues, genital system, and mediastinum. So far, the pathogenesis of IMT is still unclear, and it was initially thought to be related to trauma, infection, surgery, and other stimuli, which finally activated myofibroblasts with proliferative potential to Case Report · Kasuistik Breast Care Breast Care 2013;8:290–292 DOI: 10. It was first described in the lung, but its occurrence at various extrapulmonary sites has also been reported. In the present study, we present a case of IMT in a 56 Background: Inflammatory myofibroblastic tumor (IMT) is a rare, distinctive lesion composed of a proliferation of myofibroblastic spindle cells accompanied by an inflammatory infiltrate. IMT is typically localized, and multifocal or metastatic breast IMT, presenting l e , morphological, immunohistochemical, d r pathological fea- tumor,recurrenceofelbreast[,15],axillary hnodemetastasis,inguinalmetastasis[2],d rhnode,dadjacentb nsalsoreported. Modified radical mastectomy was performed, followed by TAC chemotherapy (taxotere, adriamycin and cyclophosphamide). While it usually occurs in the lungs, there are also reports of cases with extrapulmonary sites such as spleen, breast, maxillary sinus, epididymis, central Background: Few reports of inflammatory myofibroblastic tumor (IMT) of the breast have been published worldwide. Whether uterine IMTs occurring in the setting of pregnancy are clinically or biologically distinct from other uterine IMTs is unknown. [8,9] Familial adenomatous polyposis: Patients with familial Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. 2005. We report a case involving an elderly woman with an IMT situated on the right atrial wall. Refer to the article on inflammatory myofibroblastic tumors for a broad discussion. spleen, lymph node, breast, kidney, bladder, orbita, and central nervous system [1, 2]. IMT located in the head and neck regions is tremendously rare. J Breast Cancer, 18 (2) Myofibroblastic, fibroblastic and/or myoid lesions are rare in the breast but comprise the majority of mammary mesenchymal spindle cell lesions. IMT Definition / general. Herein, we present a non Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. Due to the scarcity of reports, their natural history, recurrence, and metastatic potential remain poorly 1. IMT is typically localized, and multifocal or metastatic Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal benign tumor which is generally seen in children and in young adults. We describe the largest cohort of IMT patients to date, aiming to further characterize this rare, poorly understood tumor. Introduction. It is usually benign, however local invasion, recurrence, malignant transformation with Also known as inflammatory pseudotumor, inflammatory myofibroblastic tumor is now considered a true low-grade neoplasm. The inflammatory myofibroblastic tumor (IMT) is an uncommon low-risk lesion with only a few cases described in the literature. Inflammatory myofibroblastic tumor of the breast is an extremely rare lesion. Myofibroblastomas are considered to be benign tumors, and they are somewhat more common in older men than in women. Ultrasound manifestations of inflammatory myofibroblastic tumor. 1a; Table 1). Radiological examination revealed a mass, measuring approximately Inflammatory myofibroblastic tumors rarely spread to other parts of the body but they are likely to recur (come back) after treatment. Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal neoplasm with intermediate biological behavior and indolent clinical manifestations (). There was one case with stomach, bladder, breast, liver, uterus, and rectum each. IMT in the esophagus is extremely rare, with only 15 case reports published in the past 20 years. The outlook of this disease has changed with time from a benign reactive process to a malignant neoplasm, based on the multiple case reports demonstrating recurrent and constant clonal genetic alterations [1-5]. A 52-year-old woman underwent a medical Breast inflammatory myofibroblastic tumors. Although some difficulties are due the fact that different names are often used to indicate the same entity, it is also true that a single Pediatric fibroblastic and myofibroblastic tumors are a relatively common group of soft-tissue proliferations that are associated with a wide spectrum of clinical behavior. Mammo Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. The Primary inflammatory myofibroblastic tumors (IMTs) of the breast are uncommon and metastasis of IMTs is extremely rare. There are three main histological Abstract. An inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of unknown pathogenesis and aggressive malignant potential with a global incidence of less than 1%[1,2]. In our opinion, the tumor-like and tumor spindle cell lesions of the breast are often underrecognized, with confusion in the distinction between reactive versus neoplastic (benign or low-grade malignant) lesions. The current study presents the case of a 56-year-old female with a Inflammatory myofibroblastic tumours (IMTs) were initially considered to be benign reactive processes, but cases with an unfavourable outcome have been reported. 20. This systematic review aims to describe the clinical presentation and compare the management options for bladder IMTs. Many different terms have been used to refer to these tumours: plasma Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor and a surrounding pseudocapsule composed of compressed breast tissue. Case report: Here, we report a unique case of an IMT coexisting with breast cancer. Although the lung is the most common site, it has been described in many other locations, including the breast; the first report of breast involvement was by Pettinato et al. Breast IMTs are easily misdiagnosed as other types of malignant lesions, and therefore there is a significant unmet need for a better preoperational differential diagnosis based on imaging Inflammatory myofibroblastic tumor (IMT) is a rare and independent soft-tissue tumor that originates from myofibroblastic cells with infiltration of inflammatory cells (mainly lymphocytes and plasma cells). These tumors contain proliferating neoplastic, fibroblastic and myofibroblastic cells, and are also characterized by chronic inflammatory infiltration by lymphocytes, Few reports of inflammatory myofibroblastic tumor (IMT) of the breast have been published worldwide. Bladder inflammatory myofibroblastic tumors (IMTs), which originate from the mesenchymal tissue, are rare neoplasms with malignant potential (). salivary glands, breast, soft tissues, and skin . Umiker et al. IMT can occur in adults at several anatomic sites, including the breast. Because of the Inflammatory myofibroblastic tumor, or IMT, forms in tissues called mucosal surfaces and mesentery. 7% of all lung tumors. We now report a case of a 37-year-old woman presenting with a mass in her Background: Inflammatory myofibroblastic tumors (IMTs) are defined as tumors composed of differentiated myofibroblastic spindle cells, usually accompanied by numerous plasma cells and lymphocytes, and classified as intermediate (occasionally metastatic) by the World Health Organization. Clinicopathological Analysis and Treatment of Adult Patients with Inflammatory Myofibroblastic Tumor: A 15-Year Single- Center Study. The clinical and pathological features of IMT in adult patients are not well understood. Inflammatory myofibroblastic tumor (IMT) is a rare disease. Inflammatory myofibroblastic tumor of soft tissue is a histologically distinctive myofibroblastic spindle cell neoplasm of borderline malignancy, classically featuring an intermixture of plasma cells and lymphocytes. To date, the natural course of this disease is not fully understood. 7% of all hepatic lesions 1. In each case, a diagnosis of inflammatory myofibroblastic tumor was made (aka, inflammatory pseudotumor). ANNDIAGPATH. Although CAFs are a major component of the breast cancer Inflammatory myofibroblastic tumor or inflammatory pseudotumor was first described by Brunn in 1932. The most common site of IMT is the lung, although it can also occur in the abdomen, pelvis, head and neck, upper Inflammatory myofibroblastic tumors can be found primarily in children and young adults, and they rarely occur in patients over 40 years old. We present the fine needle aspiration (FNA) cytology of a case of recurrent, bilateral IMT of the breast and detail the clinical course, radiologic findings, morphologic appearances Few reports of inflammatory myofibroblastic tumor (IMT) of the breast have been published worldwide. 7%). The tumor was fully excised. The tumors have been documented to occur in various anatomical sites, including the lungs, abdomen, Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm characterized by a spindle-cell proliferation with an inflammatory infiltrate. Vats Inflammatory myofibroblastic tumor (IMT) is currently classified by WHO as a soft tissue tumor composed of spindly myofibroblasts admixed with inflammatory cells We report on a case of a primary breast IMT in a postmenopausal female patient treated successfully with breast conserving surgery and review the literature pertaining to this Inflammatory myofibroblastic tumors (IMTs) are rare intermediate-grade neoplasms that have a high recurrence rate after excision and exhibit low metastatic We report these patients to emphasize the diagnostic features of inflammatory myofibroblastic tumor of the breast and discuss how they can be distinguished from Breast inflammatory myofibroblastic tumors. 1, 2 Its origin, etiology and behavior remain a matter of debate. Here, we present the clinical imaging results and report the significance of sonographic findings of breast IMT along with a review of the literature. J Breast Cancer. J Tokyo Med Univ. Approximately half of IMTs carry rearra Inflammatory myofibroblastic tumor (IMT) also known as inflammatory pseudotumor is a rare entity of neoplastic origin. To date, the natural course of this An inflammatory myofibroblastic tumor (IMT) is a neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory cells, Dr. Inflammatory pseudotumour is a generic term applied to a variety of neoplastic and non-neoplastic entities that share a common histological appearance, namely a cytologically bland spindle cell proliferation with a prominent, usually chronic inflammatory infiltrate. Here, we report a unique case of an IMT coexisting with breast cancer. Liu X, Gong C, Zhang J, Feng W, Guo Y, Sang Y, Wang C, Chen Y, Wang J, Yu L, Zhang X, Luo Z Cancer Res Treat No lesions were positive for anaplastic lymphoma kinase-1, desmin, S-100, CD34, CD21, or CD35. The Breast Inflammatory Myofibroblastic Tumor; Professional guidelines. From the extrapulmonary cases, 11% have been found in the upper Introduction. In 2020, the World Health Organization (WHO) identified IMT as a borderline tumor with potentially recurrent and rare metastatic properties (). The patient was fr Myofibroblastic CAFs are indeed key mediators of fibrotic tumor stroma, which is characterized by accumulation of extracellular matrix (ECM), increased tissue stiffness and breast cancer risk [5,6,7]. The World Health Organization (WHO) classifies inflammatory myofibroblastic tumors (IMTs) as distinct borderline lesions, while the physical history of these lesions can variably range from reactive to truly neoplastic . —. It is similar to a benign tumor in manner of spindle-cell proliferation intermixed with Myofibroblastic stromal hyperplasia (MSH) is the proposed name for a benign spindle cell proliferation of the mammary stroma, which often raises clinical and radiographic concern for a mass or a Inflammatory pseudotumor, also known as inflammatory myofibroblastic tumor and plasma cell granuloma, is an uncommon low-grade lesion composed of spindle cells admixed with mature plasma cells and Inflammatory Myofibroblastic Tumor of the Colon Simona Gurzu , Tivadar Bara , Ioan Jung Journal of Clinical Oncology 2013 31 : 10 , e155-e158 Inflammatory myofibroblastic tumors (IMTs) are uncommon, mesenchymal lesions, and malignant transformation is extremely rare. The pathogenesis of IMT is controversial (6-9). Inflammatory myofibroblastic tumor (IMT) is a lesion composed of myofibroblasts and fibroblasts with the inflammatory infiltrates of plasma cells, lymphocytes, and eosinophils (1-5). Modified radical mastectomy was performed, followed by TAC chemotherapy (taxotere, adriamycin and Inflammatory myofibroblastic tumor (IMT) is a mesenchymal spindle cell tumour with low malignant potential which is extremely rare in breasts. This is a multi-institutional review of IMT patients ≤39 years, from 2000 to 2018, Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate malignancy. Given its rarity, data are limited. Diagnostic challenges arise from the diverse pathological presentation, variable symptomatology, and lack of different imaging features. It encompasses a spectrum of myofibroblastic proliferation along with varying amount of inflammatory infiltrate. 3cm (1cm to 25cm). Its pathological characteristics may resemble other neoplasms or reactive lesions, and the treatment was limited, taking chemotherapies as the only Inflammatory Myofibroblastic Tumor of the Breast: A Case Report Ahmet Salih Karaoglu 1 , Mahmut Hudai Demir 1 , Abdullah Ayaz, Hamza Uysal, Tuce Soylemez 2 , Tunc Eren 3 , Abdullah Aydin 2 , Orhan Inflammatory myofibroblastic tumors (IMTs) of the breast are extremely uncommon lesions, usually labelled as a subgroup of inflammatory pseudotumors. The resected polyp was diagnosed by histology and immunohistochemistry as an anaplastic lymphoma kinase Fibroblastic and myofibroblastic tumors (FMTs) are tumors which develop from the mesenchymal stem cells which differentiate into fibroblasts (the most common cell type in connective tissue) and/or the myocytes/myoblasts that differentiate into muscle cells. by. Inflammatory myofibroblastic tumours (IMTs) constitute a rare group of neoplasms composed of a mixture of spindle-shaped myofibroblasts or fibroblasts and a variable amount of inflammatory cells (eosinophils, plasma cells and lymphocytes) []. Here the authors provide further insights into the spatial landscape and plasticity of Inflammatory myofibroblastic tumor of the lung has often been reported but extrapulmonary cases are rare. In all 15 cases, the original breast inflammatory An inflammatory myofibroblastic tumor (IMT) is a mesenchymal tumor with extremely low incidence. Histopathological diagnosis and The differential diagnosis of inflammatory myofibroblastic tumor of the breast includes spindle-cell (metaplastic) breast carcinoma, fibromyxoid sarcoma, malignant fibrous histiocytoma, inflammatory fibrosarcoma, extramedullary plasmacytoma, and various benign lesions, such as fibromatosis, nodular fasciitis, biopsy repair We encountered a case of inflammatory myofibroblastic tumor (IMT) of the breast with simultaneous intracranial, lung, and pancreas involvement. The European Organization for Research and Treatment of Cancer (EORTC) clinical phase II trial 90101 “CREATE” showed high antitumor activity of crizotinib, an inhibitor of anaplastic lymphoma kinase (ALK)/ROS1, in patients with advanced inflammatory myofibroblastic tumor (IMFT). According to the World Health Organization classification, mesenchymal tumors include 17 lesions of vascular, lipomatous, nerve sheath, myofibroblastic, and myogenic origin []. A woman aged 38 years with a breast mass was referred to our general surgery clinic. 1016/J. 04–1. Previously published literature mainly focused on reporting pathological analyses of LGMS, while Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. Survival in the group of tumor size smaller than 6. Objectives: To present the most important characteristics of inflammatory myofibroblastic tumours (IMTs) arising in different locations of the body with histological correlation. Yamada K, Kojika M, Matsubayashi J, et al. Some investigators are reluctant to make the diagnosis of inflammatory myofibroblastic tumor when dealing with ALK-negative lesions arising at unusual sites, including the adult breast. Riordan Azam. In 2002, the WHO officially defined it as a soft tissue tumor and named it IMT []. 2 cm × 1. spleen, breast, pancreas, liver, spermatic cord, prostate, peripheral nerves, soft tissue and orbit. To date, only six patients with ALK-positive IMT have been reported in the literature. 1 It is a soft tissue tumor, which evolves through myofibroblastic differentiation and is characterized by Inflammatory myofibroblastic tumor is an idiopathic benign mass lesion composed of fibrous tissues, myofibroblasts and marked inflammatory infiltration, predominantly plasma cells. However, IMT is identified by the Inflammatory myofibroblastic tumor is a rare benign lesion whose tumor origin is now proven. It is an intermediate malignancy tumor, which seldom presents as metastatic disease. Head and neck IMTs are rarely seen and comprise less than 5 % of Moreover, CK expression is commonly seen in other myofibroblastic proliferations, like the inflammatory myofibroblastic tumor . Materials and methods: We retrospectively searched for records of adult patients with IMT at Fudan University Shanghai Cancer INTRODUCTION. A case of inflammatory myofibroblastic tumor (low-grade malignant spindle cell tumor) of the Inflammatory myofibroblastic tumor (plasma cell granuloma). Complete surgical resection of the tumor is preferred, and it has the risk of recurrence and Inflammatory myofibroblastic tumor can be distinguished based on a circumscribed growth pattern, Zhao HD, Wu T, Wang JQ, Zhang WD, He XL, Bao GQ, Li Y, Gong L, Wang Q. We describe the largest cohort of patients with IMT to date, with an aim to further characterize this poorly understood tumor. This is a multi-institutional review of IMT patients ≤39 years, from 2000 to 2018, at 18 hospitals in the Pediatric Surgical AbstractPurpose:. There are currently no guidelines on the management of bladder IMTs. Epidemiology IMTs of the liver Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. These soft tissue tumors can occur at multiple anatomic sites, but most A myofibroblastoma is one of a group of ‘soft-tissue‘ tumors which can arise out of the ‘stromal‘ elements in breast tissue. A 16- Inflammatory myofibroblastic tumor (IMT) is currently classified by WHO as a soft tissue tumor composed of spindly myofibroblasts admixed with inflammatory cells such as plasma cells, lymphocytes, and eosinophils (Coffin and Fletcher 2013). Furthermore, little is Inflammatory myofibroblastic tumors of the breast with simultaneous intracranial, lung, and pancreas involvement: ultrasonographic findings and a review of the literature. We describe the case of a 41-year-old patient with a nodule measuring 2. 0%), and retroperitoneum (n=2, 6. As is the case for other non-small round cell sarcomas, surgical resection remains the standard treatment strategy for in Inflammatory myofibroblastic tumor (IMT) is a neoplasm of intermediate biologic potential. [1] It was first described in 1987, and since then, there have been various pathological, surgical, and radiographical publications in the literature. Clinical Presentation. Due to the scarcity of reports, their natural history, recurrence, Here, we report a case of inflammatory myofibroblastic tumor in the breast with the imaging findings of mammography, magnetic resonance imaging (MRI), and pathologic findings to improve the Myofibroblastomas are rare benign spindle cell tumors that occur within both male and female breasts. Ten patients were adults, and five were pediatric patients (aged 15 years or younger). Neoplastic cells have a myofibroblastic appearance, with relatively abundant pale to slightly or The term inflammatory myofibroblastic tumor (IMT) encompasses a diverse group of spindle cell entities that traverses a clinical and histologic spectrum, extending from reactive to benign neoplastic to highly aggressive with malignant inclinations. Due to its rarity comprehensive reports detailing clinical management and outcome(s) are sparse and often based Inflammatory myofibroblastic tumors (IMTs) are a heterogeneous group of neoplastic diseases composed of myofibroblastic spindle and inflammatory cells. The patient was positive for antinuclear, anti-mitochondrial, and anti Introduction. Data Inflammatory myofibroblastic tumor (IMT) is a very rare benign tumor that mimics malignant tumors in its aggressiveness locally and by the possibility of recurrence after surgical resection. The most common site of IMT is the lung, although it can also occur in the abdomen, pelvis, head and neck, upper The case presented here is unique in showing anaplastic lymphoma kinase 1 (ALK1) overexpression and ALK1 gene amplification in IMT of the breast in a 46-year-old woman who complained of a breast mass with palpable axillary lymph node. Because of the lack of typical imaging and clinical characteristics of IMT, it is easy to misdiagnose before operation. PubMed. As a very rare tumor, breast IMT could be easily misdiagnosed clinically and pathologically. 7% irrespective of the gender and race of the world population Introduction. Mesenchymal Tumors of the Breast: Fibroblastic/Myofibroblastic Lesions and Other Lesions. Its pathogenesis and biological behavior Moreover, CK expression is commonly seen in other myofibroblastic proliferations, like the inflammatory myofibroblastic tumor . Most of the tumors were malignant or malignant potential (89%), though local and distant metastasis rate were low (5%). In the present study, we present a case of IMT in a 56 We previously reported a case of proteomics-directed treatment of an inflammatory myofibroblastic tumor, but this is the first patient participating in our protocol that has been selected for HER2 Inflammatory myofibroblastic tumors (IMTs) have been reported to occur in multiple anatomical locations, including the lungs, bladder, spleen, breast, pancreas, liver, colon, spermatic code, prostate, and soft tissue. VGLL3 is a cofactor for TEA domain-containing transcription factors and has also been associated with breast, colon and lung cancer 60. They have previously been considered a subgroup of inflammatory pseudo-tumors (IPTs) but despite interchangeable use in the literature and similar morphology, they have different Introduction. It is histologically heterogenous, composed of spindle-shaped cells, myofibroblasts and inflammatory cells. in 19 Abstract. IMT is typically localized, and multifocal or metastatic Rationale: Inflammatory myofibroblastic tumors (IMTs), particularly breast IMTs, are rare neoplastic lesions typically associated with a favorable prognosis. Inflammatory myofibroblastic tumor (IMT) is a histologically benign ubiquitous lesion usually described in the lung [] and the orbit. In this study, we report a subset of IMTs with histologic atypia and/or clinical aggressiveness that were analyzed for clinicopathologic features, outcome, and immunohistochemical expression of anaplastic lymphoma kinase (ALK) and other Introduction. A case of inflammatory myofibroblastic tumor (low-grade malignant spindle cell tumor) of the breast. The literature mentions only a handful of Inflammatory myofibroblastic tumors (IMTs) are uncommon breast lesions that consist of spindle cells accompanied by plasma cell-rich inflammatory infiltration, which may mimic breast cancer Primary inflammatory myofibroblastic tumors (IMTs) of the breast are uncommon and metastasis of IMTs is extremely rare. A 44-year-old woman was admitted for a breast mass evaluation. It is an unusual solid tumor commonly seen in children and young adults, and can occur at any site in the body, the lung being the most common site[]. An inflammatory myofibroblastic tumor is a rare component of bone and soft-tissue sarcomas that has distinct pathological features as a lymphoplasmacytic inflammatory infiltrate. Clinicopathologic study of 20 cases with immunohistochemical and ultrastructural observations Primary inflammatory myofibroblastic tumors of the breast with metastasis: radiographic and histopathologic predictive factors. See also topic in Soft tissue chapter. The reciprocal t(1;10) The differential diagnosis includes inflammatory myofibroblastic tumor (IMT), atypical cellular myofibroma, leiomyosarcoma and nodular fasciitis among others. Objective. IMTs are defined as an extremely rare intermediate-grade malignancy (prevalence of Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. 5 x 1. Within this, inflammatory myofibroblastic tumor (IMT) has been recognized as a true neoplasm and should be considered distinct from IPT. Several other sites were reported including spleen, lymph nodes, esophagus, stomach, salivary glands, breast, epididymis, central nervous system, and soft tissues. First described by Brunn in 1937, inflammatory myofibroblastic tumour (IMT) represents an extremely rare type of inflammatory pseudo-tumour that appears most commonly in children and young individuals with a prevalence ranging from 0. An estimated 150–200 new cases are diagnosed annually in the United States (). 5cm was better compared to group of tumor size larger than 6. }, author={Elham Khanafshar and Julia Phillipson and David P. Tumors range from benign to highly malignant and from very The heterogeneity of cancer associated fibroblasts (CAFs) in breast cancer has been previously described. A number of terms have been applied to the lesion, namely, inflammatory pseudotumor, fibrous xanthoma, plasma cell granuloma, pseudosarcoma, Treatment includes corticosteroids, intravenous gamma globulin (IVIG), rituximab, and other immunosuppressive therapies. Myofibroblastic inflammatory tumors can occur in any human tissue. We present the challenges in their diagnosis and management. Whereas most have similar features to their counterparts at extramammary sites, pseudoangiomatous stromal hyperplasia is considered a breast-specific myofi A rare neoplastic lesion of the submucosal stroma, which can develop in any organ, often occurring in the lung, mesentery, omentum and the retroperitoneal region. Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. An IMT may also be defined as a plasma cell granuloma, inflammatory myofibrohistiocytic proliferation, fibroxanthoma, histiocytoma, fibrous histiocytoma, xanthomatous pseudotumor, inflammatory pseudotumor, mast cell Introduction. Other common sites are mesentery, omentum, larynx, liver spleen, and breast. A CT scan revealed a tumor with a diameter of 7 cm with sharp margins, intra-tumoral fatty components and enhancing soft tissue. The tumor microenvironment Inflammatory myofibroblastic tumor (IMT) is a rare, distinctive lesion composed of a proliferation of myofibroblastic spindle cells accompanied by an inflammatory infiltrate. A: An oval, hypoechoic mass with clear borders of approximately 4. They are composed of inflammatory cells and bland spindle cells without nuclear atypia. Commonly, this tumor only affects one organ but can occur in Inflammatory myofibroblastic tumors (IMTs) of the head and neck are frequent benign lesions and have been reported in various sites such as orbit, maxillary sinus, nasal cavity, buccal space, parotid gland, nasopharynx and larynx. Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis: a case Inflammatory pseudotumor, also known as inflammatory myofibroblastic tumor and plasma cell granuloma, is an uncommon low-grade lesion composed of spindle cells admixed with mature plasma cells and other inflammatory cells, such as histiocytes, lymphocytes, and eosinophils. 4048/jbc. They are benign lesions and more common in young patients. The World Health Organization (WHO) 2020 definition of IMT suggests that it is a distinctive, rarely metastasizing neoplasm Inflammatory myofibroblastic tumor of the breast is an extremely rare entity that can recur, with a recurrence rate of 25% . Methods: Patients (<25 years old) with IMT from 9 countries were prospectively registered via a Inflammatory myofibroblastic tumors (IMTs) of the musculoskeletal system are extremely rare benign neoplasms, and just a few cases have been described that arise from the muscles 1. Inflammatory myofibroblastic tumor (IMT) is a rare benign lesion that has similarities to malignant lesions due to possible aggressive behavior, although its specific potential for malignancy has not been determined. 2,3, Abha Gupta. Patients with muscular IMTs usually Inflammatory Myofibroblastic Tumors (IMTs) were first described in the lungs by Bunn in 1939 and the first breast case was described in 1988 by Pettinato . Here, we describe a patient diagnosed with OMS associated with a localized inflammatory myofibroblastic tumor. Interventions: Breast needle biopsy and mammary resection were performed. Extrapulmonary IMTs account for 5% of all IMTs Inflammatory myofibroblastic tumors (IMTs) of the breast are extremely uncommon lesions, usually labelled as a subgroup of inflammatory pseudotumors. Inflammatory myofibroblastic tumors of the breast with simultaneous intracranial, lung, and pancreas involvement: ultrasonographic findings and a review of Primary inflammatory myofibroblastic tumors (IMTs) of the breast are uncommon and metastasis of IMTs is extremely rare. Context. Several cases of IMT arising in various locations including the lung, bladder, trachea, and breast in association with pregnancy have been reported in the literature, and 3 cases involving the placenta have 1 Introduction. Histologically, IMTs are primarily Purpose: Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal malignancy that occurs primarily in children and adolescents. The patient has no evidence of tumor recurrence following surgical resection with 8-month follow-up. To provide an overview of currently used and recently identified IHC stains that have been implemented in the field of diagnostic breast pathology. Given its rarity, myofibroblastoma poses a challenge to pathologists when Li-Fraumeni syndrome: Patients with Li-Fraumeni syndrome (usually resulting from heritable cancer-associated changes of the TP53 tumor suppressor gene) have an increased risk of developing soft tissue tumors (mostly NRSTS), bone sarcomas, breast cancer, brain tumors, and acute leukemia. This report prompts that prosthesis implantation may cause IMT. 1. Zusammenfassung. Myofibroblastoma is a benign rare spindle-cell breast tumor, which is rare and reported to have a slight male predisposition. Inflammatory myofibroblastic tumor (IMT) is a rare tumor with low-grade malignant risk mainly occurring in soft tissues and lungs, and it is extremely rare in the breast. Solitary fibrous tumor (SFT) cells are enriched with the alternating distribution of different shapes of collagen fiber bundles INTRODUCTION. 27, 56 Review of the literature on the topic shows that most lesions, regardless of ALK-1 expression, have a benign clinical course after follow-up of 1538 Background: Inflammatory Myofibroblastic Tumors (IMT) are tumors that morphologically traverse the neoplastic and inflammatory realms. Inflammatory Myofibroblastic Tumor (IMT) is a rare mesenchymal tumor which can occur at any age, but has a predilection for children, adolescents, and young adults (). IMT of the stomach is uncommon, and because it may be confused with gastrointestinal stromal tumor (GIST) go back to reference Yamada K, Kojika M, Matsubayashi J, et al. Methods: To review the symptoms and main radiological findings of IMTs. Due to the scarcity of reports, their natural history, Introduction. Mammogram and ultrasound revealed a well-circumscribed Inflammatory myofibroblastic tumor presenting as a conjunctival lesion in the pediatric population is exceedingly rare, and there is a paucity of data on how best to manage these patients after surgical intervention. Due to the scarcity of reports, their natural history, recurrence, and metastatic potential remain poorly defined. IMT represents the neoplastic subset of the family of inflammatory pseudotumors, an umbrella term for spindle cell proliferations of uncertain histogenesis with a variable The World Health Organization (WHO) classifies inflammatory myofibroblastic tumors (IMTs) as distinct borderline lesions, while the physical history of these lesions can variably range from reactive to truly neoplastic . These tumors have been divided into the following categories on the basis of their biologic behavior: benign (eg, myositis ossificans, myofibroma, fibromatosis colli), Inflammatory myofibroblastic tumor (IMT) of the breast, first reported at 1988 (1), is now considered as a true low-grade neoplasm and mixture of spindle cells and chronic inflammatory cells, such Inflammatory myofibroblastic tumor of the breast is a rare and intermediate (rarely metastasizing) malignant potential tumor and, due to recurrence and metastasis risk, complete excision with negative margins and regular follow up plays a critical role in treating of inflammatory my ofibro Blastic tumors. @article{Khanafshar2005InflammatoryMT, title={Inflammatory myofibroblastic tumor of the breast. 5 ± 5. Inflammatory myofibroblastic tumors (IMTs) are rare and primarily occur in patients <16 years of age (). As a result of overlapping morphologies and a lack of large-scale studies on these tumors, practices are often heterogeneous and slow to evolve. CAFs coexist as heterogeneous populations with potentially different biological functions. Please refer to the article on inflammatory myofibroblastic tumors for a broad discussion. FMTs are a heterogeneous group of soft tissue neoplasms (i. Clinicopathological and genetic analysis of a case with evidence for clonality. breast, spleen, kidneys, liver, stomach, colon, and ampulla of Vater . Inflammatory myofibroblastic tumor (IMT) of the uterus is a rare mesenchymal tumor with largely benign behavior; however, a small subset demonstrate aggressive behavior. IMT has a predilection for the lung, abdomen, pelvis, and retroperitoneum, however, can affect any part of the body. Inflammatory myofibroblastic tumors (IMTs) are uncommon breast lesions that consist of spindle cells accompanied by plasma cell-rich inflammatory infiltration, which may mimic breast cancer clinico-radiologically. doi: 10. 1 Introduction. The whole mark of these tumors is the spindle The initial clinical diagnosis was breast cancer, and the patient underwent a conservative excision with apparently negative margins and an axillary lymph node excisional biopsy. 5 cm in the superior lateral quadrant of the left breast. Inflammatory myofibroblastic tumor (IMT) is a rare type of mesenchymal tumor with malignant potential that is frequently observed in patients who are <16 years old, and is rarely observed in adults (). We report on a case of a primary breast IMT Inflammatory pseudotumors (IPT) are a broad category of rare inflammatory conditions presenting as a mass. The mammograms of breast LGMS are generally irregular shapes and high density, with a lack of encapsulation . Abstract. Key words: breast tumor, inflammatory myofibroblastic tumor, ALK gene. A 16-year-old girl with a history of Inflammatory Myofibroblastic Tumor of Breast is a very rare and mostly benign tumor affecting the breast. IMT usually starts in the lung, but it can also begin in many other places. The tumor cells may have a certain genetic change called a translocation (part of one chromosome switches places with part of another chromosome). LGMS of the breast are tumors of stromal origin and are etiologically more likely to have Inflammatory myofibroblastic tumor (IMT) is a very rare benign tumor that mimics malignant tumors in its aggressiveness locally and by the possibility of recurrence after surgical resection. Background: Inflammatory myofibroblastic tumors (IMTs) are a distinct entity of mesenchymal tumors. Although it has been described using various terms, such as “inflammatory pseudotumor” or “plasma cell granuloma”, IMT is the more appropriate term as recognized in the 2002 World Health Introduction. Inflammatory myofibroblastic tumours (IMTs), also known as inflammatory pseudotumours, include Inflammatory myofibroblastic tumor occurs most frequently in children and young adults. Here we describe a case of inflammatory myofibroblastic tumor of the breast in a 60-year-old woman. The patient had a smooth recovery post-surgery and remained free of recurrence for three years. Furthermore, primary anaplastic lymphoma kinase (ALK)-positive IMT of the breast is extremely rare. We now report a case of a 37-year-old woman presenting with a mass in her Mesenchymal breast tumors are a rare and diverse group of tumors that present some of the most challenging cases for multidisciplinary breast cancer teams. Hintergrund: Inflammatorische myofibroblastische Tumoren (IMT) sind eine Untergruppe der inflammatorischen Pseudotumoren (IPT). LGMS of the breast are tumors of stromal origin and are etiologically more likely to have We encountered a case of inflammatory myofibroblastic tumor (IMT) of the breast with simultaneous intracranial, lung, and pancreas involvement. Low grade mesenchymal neoplasm that can arise in the colonic wall or mesentery, usually of children. 2015 Jun;18(2):200-205. 4,5, Here, we report a case of inflammatory myofibroblastic tumor in the breast with the imaging findings of mammography, magnetic resonance imaging (MRI), and We report these patients to emphasize the diagnostic features of inflammatory myofibroblastic tumor of the breast and discuss how they can be distinguished from Myofibroblastoma of the breast is a benign tumor of mesenchymal origin associated with the deletion of chromosome 13q14, similar to spindle cell lipoma and cellular angiofibroma. IMTs most commonly occur in the lungs of children and young adults, followed by the head and neck[], liver[], pancreas[], genitourinary Introduction. However, the or Primary inflammatory myofibroblastic tumor (IMT) of the breast is extremely rare; only 19 cases have been reported in the English literature. It represents 0. The clinical and imaging characteristics of this lesion are similar to that of a A case of a primary breast IMT in a postmenopausal female patient treated successfully with breast conserving surgery is reported on and the literature pertaining to this rare entity is reviewed. [32]- Clinicopathological Features of Inflammatory Myofibroblastic Tumor in the Breast We report a case of an intestinal polyp causing intussusception in a 2-month-old boy. Historically, the literature regarding IMT has been confined to small one organ case series, with few reviews encompassing multiple anatomic sites, and little data regarding adjuvant treatment. 1, Miralem Mrkonjic. IMT is a rare tumor Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor of intermediate malignant potential that predominantly affects children, adolescents and young adults. jo 1 Department of Surgery, King Hussein Cancer Center, Amman, Introduction. Himanshu J. Inflammatory myofibroblastic tumors (IMTs) of the breast represent extremely rare lesions. Crizotinib (Xalkori) has received approval from the FDA for the treatment of patients with unresectable, recurrent, or refractory ALK-positive inflammatory myofibroblastic tumors who are 1 year of age or older, according to Low-grade myofibroblastic sarcoma (LGMS) is a rare type of malignant myofibroblastic tumor. 2% of all lung tumors. Though it may occur to any body part, the most common location is the limbs, head and neck region, particularly the tongue and mouth []. Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate biological potential with a predilection for the lung and abdominopelvic region. . While clinicopathologic features have been previously associated with aggressive behavior, these reports are based on small series, and these features are TSPAN8 + myofibroblastic cancer–associated fibroblasts Recent studies have revealed a strong heterogeneity within the CAF population manifested as myofibroblastic CAFs (myCAFs), inflammatory/growth high-throughput single-cell flow cytometry analysis (FACSymphony) was performed on a large cohort of human breast 10024 Background: Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm of intermediate malignancy, predominantly seen in children and young adults. 2013;5(1):97–100. kcjjw pir baax qhxrbx pfy arxjt gte yihcq odgakc iww